Histopathological Evaluation of the Effect of Dextromethorphan and Guaifenesin on the Lung And Kidney Tissues in Albino Rats
DOI:
https://doi.org/10.59890/k1bwvd23Keywords:
Histopathological Evaluation, Effect, Guaifenesin, Kidney TissuesAbstract
Dextromethorphan and guaifenesin are two commonly used medications for the treatment of cough and colds. While their efficacy in alleviating respiratory symptoms is well documented, comprehensive data on their histopathological impact on vital organs is limited. This study determined the effect of the drugs on the lungs and kidney tissues of Albino rats. Twenty four adult albino rats weighing 110±20g were grouped into 4, of 6 rats each. Group A received only normal feed and water daily and served as the control. Groups B, C and D were administered with 0.1ml, 0.5ml and 1ml respectively with oral dextromethorphan and guaifenesin for 28 days. Blood was collected into lithium heparin for biochemical analysis, while the liver and kidney tissues were fixed in 10% formol saline, processed by the paraffin wax method and stained with H&E for examination. Biochemical analysis showed no significant changes in the values of total protein, albumin and Malondialdehyde, while there was a reduction in the values globulin from 8.10 ± 0.59 to 3.85 ± 2.56, glutathione increased from 112.64 to 462.03 ± 1.88 in the low and high doses. Histological findings showed no significant alterations in lungs and kidney tissues
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